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Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. [1]
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Shingles occurs only in people who have been previously infected with VZV; although it can occur at any age, approximately half of the cases in the United States occur in those aged 50 years or older. [37] Shingles can recur. [38] In contrast to the frequent recurrence of herpes simplex symptoms, repeated attacks of shingles are unusual. [39]
The blisters fill with pus, break open (3), crust over (4), and finally disappear. This process takes four to five weeks. A painful condition called post-herpetic neuralgia can sometimes occur. This condition is thought to be caused by damage to the nerves (5), and can last from weeks to years after the rash disappears.
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This list includes conditions that are not diseases, but symptoms or syndromes common to autoimmune disease. [118] Chronic fatigue syndrome; Complex regional pain syndrome; Eosinophilic esophagitis; Gastritis; POEMS syndrome [119] Raynaud's phenomenon; Primary immunodeficiency [120] Pyoderma gangrenosum
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