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Despite the known association with IFN-γ, erythema multiforme is not considered a humorally-mediated autoimmune reaction. [8] Rarely, some patients may suffer from a persistent and treatment-resistant form of erythema multiforme caused by the Epstein-Barr virus. This pathology is distinct from the recurrent cases that sometimes arise from HSV ...
Some of the most severe and life-threatening examples of drug eruptions are erythema multiforme, Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), hypersensitivity vasculitis, drug induced hypersensitivity syndrome (DIHS), erythroderma and acute generalized exanthematous pustulosis (AGEP). [4]
In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment. The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation. [2] According to some sources, there are two conditions included on a spectrum of this same disease process: Stevens–Johnson syndrome (SJS)
Erythema multiforme (EM) is usually a reaction of the skin and mucous membranes that occurs suddenly. [1] It appears as a symmetrical rash and may include the mucous membrane lesions. This means that the body is sensitive to something that causes the skin and mucous membranes to react. The more common mild form is refer to as EM minor.
Target lesions are the typical lesions of erythema multiforme, in which a vesicle is surrounded by an often hemorrhagic maculopapule. Erythema multiforme is often self-limited, of acute onset, resolves in three to six weeks, and has a cyclical pattern. Its lesions are multiform (polymorphous) and include macules, papules, vesicles, and bullae.
Erythema nodosum: Large red bumps that seem to bruise and are tender to touch Anywhere Psoriasis: White, scaly rash over red, flaky, irritated skin Elbows and knees Erythema multiforme: Red, blotchy rash, with "target like" hives or sores. Anywhere Measles: Red rash that is raised with a fever or sore throat.
Smooth red-topped small papules which merge into plaques, small fluid-filled blisters (papulovesicles) [2] and less commonly target-shaped lesions which look like erythema multiforme may be visible. [5] In addition, it may occur in other parts of the body in some people treated for inflammatory skin diseases with phototherapy. [2]
Erythema (Ancient Greek: ἐρύθημα, from Greek erythros 'red') is redness of the skin or mucous membranes, caused by hyperemia (increased blood flow) in superficial capillaries. [1] It occurs with any skin injury, infection, or inflammation .