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A classic example of a syncytium is the formation of skeletal muscle.Large skeletal muscle fibers form by the fusion of thousands of individual muscle cells. The multinucleated arrangement is important in pathologic states such as myopathy, where focal necrosis (death) of a portion of a skeletal muscle fiber does not result in necrosis of the adjacent sections of that same skeletal muscle ...
Myoblasts (cells with a single nucleus, represented in violet) fusing together to form muscle fibers (multinucleated muscle cells) during myogenesis. Myogenesis is the formation of skeletal muscular tissue, particularly during embryonic development.
A skeletal muscle cell is long and threadlike with many nuclei and is called a muscle fiber. [3] Muscle cells develop from embryonic precursor cells called myoblasts. [1] Skeletal muscle cells form by fusion of myoblasts to produce multinucleated cells in a process known as myogenesis.
Skeletal muscle cells are the individual contractile cells within a muscle, and are often termed as muscle fibers. [3] A single muscle such as the biceps in a young adult male contains around 253,000 muscle fibers. [22] Skeletal muscle fibers are multinucleated with the nuclei often referred to as myonuclei.
Multinucleate cells (also known as multinucleated cells or polynuclear cells) are eukaryotic cells that have more than one nucleus, i.e., multiple nuclei share one common cytoplasm. Mitosis in multinucleate cells can occur either in a coordinated, synchronous manner where all nuclei divide simultaneously or asynchronously where individual ...
Striated skeletal muscle cells in microscopic view. Skeletal muscle is broadly classified into two fiber types: type I (slow-twitch) and type II (fast-twitch). Type I, slow-twitch, slow oxidative, or red muscle is dense with capillaries and is rich in mitochondria and myoglobin, giving the muscle tissue its characteristic red color.
The fibres of striated muscle have a cylindrical shape with blunt ends, whereas those in smooth muscle are spindle-like with tapered ends. Striated muscle tissue has more mitochondria than smooth muscle. Both smooth muscle cells and cardiac muscle cells have a single nucleus, and skeletal muscle cells have many nuclei. [6]
These cells are capable of rapid proliferation under high serum conditions and differentiation into myotubes under low serum conditions. Mononucleated myoblasts can later fuse to form multinucleated myotubes under low serum conditions or starvation, leading to the precursors of contractile skeletal muscle cells in the process of myogenesis. [3]