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Ibuprofen is also available as a transdermal gel (e.g. Ibuleve Maximum Strength) for the management of musculoskeletal pain. Each application of gel contains between 50 and 125 mg of ibuprofen. b) Discuss why a smaller dose of ibuprofen may be used in the transdermal gel than in the oral tablets for the management of muscular pain. (30 % marks)
Ibuprofen is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic, and antipyretic activity. More in detail, ibuprofen can perform these activities by inhibiting cyclooxygenase (COX). Ibuprofen works by inhibiting COX-2 consequentially preventing the synthesis of prostaglandins responsible for fever, inflammation, and pain.
In the case study ibuprofen was utilised to manage the painful symptoms of the patient. The precise mechanism of action of ibuprofen is unidentified. It is inhibits cyclo-oxygenase non- selectively which is an enzyme participating in synthesis of prostaglandin through the arachidonic acid pathway.
Drug Classification. Drugs are classified by their chemical family, physiological or therapeutic effect. Medicinal drugs can firstly be classified into prescription drugs, or non-prescription drugs - commonly referred to as over the counter (OTC) drugs. OTC drugs can include remedies for common ailments, or drugs in a lower dosage than would be ...
Thin film medications utilise absorption through the mouth (buccal) or small intestines as a mechanism of action. The drug itself is composed of a film of hydrophilic polymers which dissolves rapidly on the tongue, allowing the drug present on the film to enter the systemic circulation via the process off dissolution; where the solids of the ...
The mechanism of action of paracetamol is not completely understood, but it is believed to reduce pain by interrupting or suppressing pain signals along the nerves. Paracetamol has no significant action on COX-1 and COX-2 enzymes, which explains its lack of anti-inflammatory action and the lack of gastrointestinal (GI) side effects (Waterfield ...
By a mechanism termed “transrepression”, glucocorticoids down regulate gene transcription commonly overexpressed during chronic non-resolving inflammation, including NF-kapaB and AP-1. These genes encode pro-inflammatory cytokines (eg IL-10) and chemokines, cell adhesion molecules and key enzymes involved in the initiation and/or ...
Introduction. Gibbs' Reflective Cycle was developed by Graham Gibbs in 1988 to give structure to learning from experiences. It offers a framework for examining experiences, and given its cyclic nature lends itself particularly well to repeated experiences, allowing you to learn and plan from things that either went well or didn’t go well.
Communication Mechanism System. Info: 3076 words (12 pages) Nursing Essay Published: 11th Feb 2020. Explain the importance of intercellular communication and describe the mechanism involved. Intercellular communication is important because it assist the nervous system to elongate the long-term process as growth, development, or reproduction.
The role of insulin in treatment for diabetes mellitus is crucial as it is clear that it is an effective hypoglycaemic agent in both type 1 and 2. Knowledge of its mechanism of action and treatment methods are crucial to a pharmacist and integrated into both clinical and community care. A pharmacist role in treating Diabetes consists of ...