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The participant is told to expect toxic symptoms due to the release of poisons or radiation from their body fat. [16] Thus the effects of niacin overdose, which include skin irritation, flushing, dizziness and headache, are interpreted as a positive effect of the program. [7] [16] [17]
Early symptoms of serious liver damage include nausea, vomiting and abdominal pain, followed by jaundice and pruritus. The mechanism is thought to be a direct toxicity of elevated serum niacin. Lowering dose or switching to the immediate release form can resolve symptoms. In rare instances the injury is severe, and progresses to liver failure. [11]
A 2022 study published in the journal Liver Transplantation found that drug-induced acute liver failure tied to herbal and dietary supplements had increased eightfold from 1995 through 2020.
Supplements That Damage the Liver The supplements the study mentioned include: Ashwagandha , used to support the nervous and endocrine systems; improve sleep; and boost mood, energy and immune levels
The US Recommended Dietary Allowance for niacin for adult women is 14 mg/day and for adult men 16 mg/day. Niacin is available as a prescription product, either immediate release (500 mg tablets; prescribed up to 3,000 mg/day) or extended release (500 and 1,000 mg tablets; prescribed up to 2,000 mg/day).
"Liver damage has been more commonly associated with taking green tea extract (GTE), which contains higher doses of EGCG." ... "A review of the literature by the European Food Safety Authority ...