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Nature Reviews Drug Discovery is a monthly peer-reviewed review journal published by Nature Portfolio. It was established in 2002 [ 1 ] and covers drug discovery and development. The editor-in-chief is Peter Kirkpatrick. [ 2 ]
npj series. The Nature Partner Journals series, abbreviated npj, is a series of online-only, open access, journals.It was launched in April 2014 with three journals: npj Primary Care Respiratory Medicine, npj Biofilms and Microbiomes, and npj Schizophrenia.
Nature Protocols; Nature Reviews Drug Discovery; Oecologia; Oikos; Open Life Sciences; PeerJ; Philosophical Transactions of the Royal Society B; PLOS Biology; Quarterly Review of Biology; Revista Chilena de Historia Natural; Revista de Biologia; The Scientific World Journal; Theoretical Biology and Medical Modelling; Zeitschrift für Naturforschung
A hook effect is commonly observed with high concentrations of PROTACs due to the bifunctional nature of the degrader. [15] Currently, pVHL and CRBN have been used in preclinical trials as E3 ligases. [15] However, there still remains hundreds of E3 ligases to be explored, with some giving the opportunity for cell specificity.
Drug Delivery; Drug Design, Development and Therapy; Drug Development and Industrial Pharmacy; Drug Discovery Today; Drug, Healthcare and Patient Safety; Drug Safety; Drug Metabolism Reviews; Drug Testing and Analysis; European Heart Journal - Cardiovascular Pharmacotherapy; European Journal of Pharmaceutical Sciences
Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major role as starting material for drug discovery. [56] A 2007 report [ 57 ] found that of the 974 small molecule new chemical entities developed between 1981 and 2006, 63% were natural derived or semisynthetic derivatives ...
Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.It includes preclinical research on microorganisms and animals, filing for regulatory status, such as via the United States Food and Drug Administration for an investigational new drug to initiate clinical trials on humans, and may ...
Nature Reviews Drug Discovery; Nature Reviews Earth & Environment; Nature Reviews Endocrinology; Nature Reviews Gastroenterology & Hepatology; Nature Reviews Genetics;