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Grünenthal paid another €50 million into the foundation in 2008. On 31 August 2012, Grünenthal chief executive Harald F. Stock — who served as the chief executive officer of Grünenthal GmbH from January 2009 to May 28, 2013 — apologized for the first time for producing the drug and remaining silent about the birth defects. [48]
Thalidomide is a known human teratogen and carries an extremely high risk of severe, life-threatening birth defects if administered or taken during pregnancy. [6] It causes skeletal deformities such as amelia (absence of legs and/or arms), absence of bones, and phocomelia (malformation of the limbs).
McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, [9] after a midwife named Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. [10]
DES gained notoriety when it was shown to cause a rare vaginal tumor in girls and young women who had been exposed to this drug in utero.In 1971, the New England Journal of Medicine published a report showing that seven of eight girls and young women (ages 14 to 22) who had been diagnosed with vaginal clear cell adenocarcinoma had been exposed prenatally to DES. [5]
Stanley believed that his experiments would rejuvenate old men, control crime (which he believed had biological causes), and prevent the "unfit" from reproducing. [ 12 ] [ 13 ] From 1955 to 1960, Sonoma State Hospital in northern California served as a permanent drop-off location for mentally disabled children diagnosed with cerebral palsy or ...
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Some studies have raised concerns about a potential link between the widely used type 2 diabetes drug metformin and an increased risk of conceiving a baby with birth defects. But new research now ...
Phocomelia is a congenital condition that involves malformations of human arms and legs which result in a flipper-like appendage. [1] [2] A prominent cause of phocomelia is the mother being prescribed the use of the drug thalidomide during pregnancy; however, the causes of most cases are to be determined.
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