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Reed–Sternberg cells are CD30 and CD15 positive except in the lymphocyte predominance type where they are negative, but are usually positive for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin lymphoma – the absence of Reed–Sternberg cells has very high negative predictive value.
Reed-Sternberg and Hodgkin (RSH) cells are rarely seen, and immunohistochemistry shows a different pattern on the malignant cells; RSH cells typically express CD15 and CD30, whereas LP cells lack expression of these markers, but express B cell markers like CD20, CD22, and CD79a and also express the common leukocyte antigen CD45, which is ...
The Reed–Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45−, CD30+, CD15+/− immunophenotype. In approximately 50% of cases, the Reed–Sternberg cells are infected by the Epstein–Barr virus. [39]
Reed–Sternberg cell variants and inflammation, usually broad sclerotic bands that consist of collagen CD15, CD30 Most common in young adults, often arises in the mediastinum or cervical lymph nodes. Mixed cellularity Hodgkin lymphoma; Second-most common form of Hodgkin lymphoma Many classic Reed–Sternberg cells and inflammation CD15, CD30
It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands. [ citation needed ] The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first ...
CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. [8] CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma. [9]
Type II PEL also tends to involve malignant plasmablasts, anaplastic cells, and/or Reed-Sternberg-like cells that have somewhat different expression patters of protein markers (e.g. the malignant cells in Type II PEL frequently express CD20 but often do not express CD30) and gene abnormalities (e.g. the malignant cells in Type II PEL more ...
Micrograph showing a small B-cell lymphoma compatible with follicular lymphoma. H&E stain. Category: Histopathology of follicular lymphoma: Hodgkin's lymphoma: Micrograph of a lymph node in Hodgkin's lymphoma with the characteristic Reed-Sternberg cell. RS cell is a large cell with abundant amophophilic cytoplasm and binucleate mirror image nuclei.