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Coenzyme Q 10 (CoQ 10 / ˌ k oʊ k j uː ˈ t ɛ n /), also known as ubiquinone, is a naturally occurring biochemical cofactor (coenzyme) and an antioxidant produced by the human body. [ 1 ] [ 2 ] [ 3 ] It can also be obtained from dietary sources, such as meat, fish, seed oils, vegetables, and dietary supplements .
A ubiquinol is an electron-rich (reduced) form of coenzyme Q (ubiquinone). The term most often refers to ubiquinol-10, with a 10-unit tail most commonly found in humans.. The natural ubiquinol form of coenzyme Q is 2,3-dimethoxy-5-methyl-6-poly prenyl-1,4-benzoquinol, where the polyprenylated side-chain is 9-10 units long in mammals.
The risk of statin-induced rhabdomyolysis increases with older age, use of interacting medications such as fibrates, and hypothyroidism. [95] [96] Coenzyme Q10 (ubiquinone) levels are decreased in statin use; [97] CoQ10 supplements are sometimes used to treat statin-associated myopathy, though evidence of their efficacy is lacking as of 2017. [98]
Mitoquinone mesylate (MitoQ) is a synthetic analogue of coenzyme Q10 which has antioxidant effects. It was first developed in New Zealand in the late 1990s. [ 1 ] It has significantly improved bioavailability and improved mitochondrial penetration compared to coenzyme Q10, [ 2 ] [ 3 ] and has shown potential in a number of medical indications ...
Coenzyme Q 10 deficiency is a deficiency of coenzyme Q 10. It can be associated with COQ2, APTX, PDSS2, PDSS1, CABC1, and COQ9. [1] Some forms may be more treatable ...
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