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  2. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    [11] [185] [186] Other known but more minor metabolites of spironolactone include 7α-thiospironolactone (7α-TS), which is an important intermediate to the major metabolites of spironolactone, [17] as well as the 7α-methyl ethyl ester of spironolactone and the 6β-hydroxy-7α-methyl ethyl ester of spironolactone.

  3. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of...

    [61] [62] [35] Levels of free testosterone were unchanged, however, suggesting that the antiandrogenic efficacy of spironolactone was due exclusively to direct AR blockade. [ 61 ] [ 62 ] In addition, other studies have found that 100 mg/day spironolactone is significantly or near-significantly inferior to 500 mg/day flutamide in improving ...

  4. 7α-Thiomethylspironolactone - Wikipedia

    en.wikipedia.org/wiki/7α-Thiomethylspironolactone

    Spironolactone is a prodrug with a short terminal half-life of 1.4 hours. [5] [6] [7] The active metabolites of spironolactone have extended terminal half-lives of 13.8 hours for 7α-TMS, 15.0 hours for 6β-OH-7α-TMS, and 16.5 hours for canrenone, and accordingly, these metabolites are responsible for the therapeutic effects of the drug. [5] [6]

  5. Spironolactone: 11 things a dermatologist wants you to know ...

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  6. I Ate a High-Protein Breakfast for Two Weeks—Here’s What Happened

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    This can result in an increased sense of fullness and a sustained energy release to power your body until your next meal. Research has also found that eating protein burns more calories than carbs ...

  7. Potassium-sparing diuretic - Wikipedia

    en.wikipedia.org/wiki/Potassium-sparing_diuretic

    Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent; Finerenone – non-steroidal, more selective and potent than spironolactone and eplerenone; Canrenone – very limited use

  8. 16 Masturbation Secrets That Will Just Make the Whole Thing ...

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    "To prevent this from happening, make sure you switch up the grip and stroking speed, so you're used to ejaculating in different ways." 9) Try edging. The 5-minute speed jerk is fine for most days.

  9. Eplerenone - Wikipedia

    en.wikipedia.org/wiki/Eplerenone

    Eplerenone may have a lower incidence than spironolactone of sexual side effects such as feminization, gynecomastia, impotence, low sex drive and reduction of size of male genitalia. [18] This is because other antimineralocorticoids have structural elements of the progesterone molecule, causing progestogenic and antiandrogenic outcomes. [ 4 ]