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[61] [62] [35] Levels of free testosterone were unchanged, however, suggesting that the antiandrogenic efficacy of spironolactone was due exclusively to direct AR blockade. [ 61 ] [ 62 ] In addition, other studies have found that 100 mg/day spironolactone is significantly or near-significantly inferior to 500 mg/day flutamide in improving ...
[11] [185] [186] Other known but more minor metabolites of spironolactone include 7α-thiospironolactone (7α-TS), which is an important intermediate to the major metabolites of spironolactone, [17] as well as the 7α-methyl ethyl ester of spironolactone and the 6β-hydroxy-7α-methyl ethyl ester of spironolactone.
Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent; Finerenone – non-steroidal, more selective and potent than spironolactone and eplerenone; Canrenone – very limited use
It is unknown if GLP-1 agonists or dual/triple agonists of GLP-1 and/or the glucagon or GIP receptors act solely by reducing energy intake or if they also increase energy expenditure. [15] Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with certain rare genetic conditions that cause obesity. It is less ...
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alive is a monthly Canadian natural health and wellness magazine. [1] The magazine provides readers with information on leading healthy lifestyles. Topics that it covers include natural health, organics, fitness, beauty, nutrition, holistic healing, emotional health and sustainability.
glow was founded in 2002. The magazine was part of Shoppers Drug Mart. [3] It was published by Rogers Communications in Toronto from its start to 2011. [4] St. Joseph Communications re-launched the magazine as a publisher with the May 2012 issue as "Canada's Beauty Expert".
Health topics featured in the magazine include fibromalgia, cancer, joint pain, menopause, allergies and celiac disease. [4] Beauty topics covered in the magazine include hair removal, winter skin care, lip care, wrinkles-anti-aging, and acne treatments. [4] In 2011 the circulation of Viva was 45,000 copies. The magazine stopped printing copies ...