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This is an accepted version of this page This is the latest accepted revision, reviewed on 28 January 2025. "Skin pigmentation" redirects here. For animal skin pigmentation, see Biological pigment. Extended Coloured family from South Africa showing some spectrum of human skin coloration Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among ...
The human skin is the outer covering of the body and is ... protein-coding genes are expressed in the skin. ... in baseline nutritional status affects skin condition. ...
Global frequency distribution of the SLC24A5 gene's ancestral Ala111 allele (yellow) and its derived Ala111Thr allele (blue). SLC24A5 appears to have played a key role in the evolution of light skin in humans of European ancestry. The gene's function in pigmentation was discovered in zebrafish as a result of the positional cloning of the gene ...
Although, in general, human beings possess a similar concentration of melanocytes in their skin, the melanocytes in some individuals and ethnic groups produce variable amounts of melanin. The ratio of eumelanin (74%) and pheomelanin (26%) in the epidermis is constant regardless of the degree of pigmentation. [ 27 ]
Several genes factor into determining a person's natural skin color, so modifying only one of those genes can change skin color slightly or in some cases, such as for SLC24A5, moderately. Many disorders with genetic components are polygenic, including autism , cancer , diabetes and numerous others.
X-linked ichthyosis (abbreviated XLI) is a skin condition caused by the hereditary deficiency of the steroid sulfatase (STS) enzyme that affects 1 in 2000 to 1 in 6000 males. [2] XLI manifests with dry, scaly skin [3] and is due to deletions [4] [5] or mutations [6] in the STS gene.
Light skin is a human skin color that has a low level of eumelanin pigmentation as an adaptation to environments of low UV radiation. [ 1 ] [ 2 ] Due to migrations of people in recent centuries, light-skinned populations today are found all over the world.
List of genes mutated in cutaneous conditions; List of genes mutated in pigmented cutaneous lesions; List of histologic stains that aid in diagnosis of cutaneous conditions; List of human leukocyte antigen alleles associated with cutaneous conditions; List of immunofluorescence findings for autoimmune bullous conditions