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Inner ear regeneration is the biological process by which the hair cells and supporting cells (i.e. Hensen's cells and Deiters cells) of the ear proliferate (cell proliferation) and regrow after hair cell injury. This process depends on communication between supporting cells and the brain.
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The TM is a gel-like structure containing 97% water. Its dry weight is composed of collagen (50%), non-collagenous glycoproteins (25%) and proteoglycans (25%). [1] Three inner-ear specific glycoproteins are expressed in the TM, α-tectorin, β-tectorin and otogelin.
The olivocochlear system is a component of the auditory system involved with the descending control of the cochlea.Its nerve fibres, the olivocochlear bundle (OCB), form part of the vestibulocochlear nerve (VIIIth cranial nerve, also known as the auditory-vestibular nerve), and project from the superior olivary complex in the brainstem to the cochlea.
It is separated from the cochlear duct by the basilar membrane, and it extends from the round window to the helicotrema, where it continues as vestibular duct. The purpose of the perilymph-filled tympanic duct and vestibular duct is to transduce the movement of air that causes the tympanic membrane and the ossicles to vibrate causing movement ...
While hair cells are generally not replaced through cell regeneration, [131] mechanisms are being studied to induce replacement of these important cells. [132] One study involves the replacement of damaged hair cells with regenerated cells, via the mechanism of gene transfer of atonal gene Math1 to pluripotent stem cells within the inner ear ...
Hearing: Cochlear duct: fluid waves in the endolymph of the cochlear duct stimulate the receptor cells, which in turn translate their movement into nerve impulses that the brain perceives as sound. Balance: Semicircular canals: angular acceleration of the endolymph in the semicircular canals stimulate the vestibular receptors of the endolymph.