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  2. Tumor M2-PK - Wikipedia

    en.wikipedia.org/wiki/Tumor_M2-PK

    M2-PK, as measured in feces, is a potential tumor marker for colorectal cancer.When measured in feces with a cutoff value of 4 U/ml, its sensitivity has been estimated to be 85% (with a 95% confidence interval of 65 to 96%) for colon cancer and 56% (confidence interval 41–74%) for rectal cancer. [1]

  3. M2-PK Test - Wikipedia

    en.wikipedia.org/wiki/M2-PK_Test

    An elevated concentration of M2-PK in the stool should always be clarified by undergoing colonoscopy. The gold standard of early detection of colon polyp/cancer is the invasive colonoscopy, but with high expense about $557, while tumor marker M2-PK Test expense only about $15-$25. The invasive colonoscopy makes acceptance of it low among ...

  4. Warburg effect (oncology) - Wikipedia

    en.wikipedia.org/wiki/Warburg_effect_(oncology)

    Tumor M2-PK is produced in all rapidly dividing cells and is responsible for enabling cancer cells to consume glucose at an accelerated rate; on forcing the cells to switch to pyruvate kinase's alternative form by inhibiting the production of tumor M2-PK, their growth was curbed. The researchers acknowledged the fact that the exact chemistry of ...

  5. Tumor marker - Wikipedia

    en.wikipedia.org/wiki/Tumor_marker

    If the quantity stays the same during treatment it can indicate that the treatment isn't working, and an alternative treatment should be considered. Rising levels of tumor marker does not necessarily reflect a growing malignancy but can result from things like unrelated illnesses. Reflect the stage of cancer

  6. Irinotecan - Wikipedia

    en.wikipedia.org/wiki/Irinotecan

    Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. [8] For colon cancer it is used either alone or with fluorouracil. [8] For small cell lung cancer it is used with cisplatin. [8] It is given intravenously. [8]

  7. Tumor hypoxia - Wikipedia

    en.wikipedia.org/wiki/Tumor_hypoxia

    Pyruvate kinase M2 is often considered the main regulator of cancer metabolism with roles in various parallel, feed-forward, positive and negative feedback mechanisms. The genetic difference between pyruvate kinase M1 and pyruvate kinase M2 is only 22 out of 531 amino acids which makes an immense difference.

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