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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
Some medications may be used to treat persistent hiccups, per the Mayo Clinic, such as baclofen, chlorpromazine and metoclopramide. In severe cases, nerve blocks or surgical procedures may be ...
Baclofen also inhibits neural function presynaptically, by reducing calcium ion influx, and thereby reducing the release of excitatory neurotransmitters in both the brain and spinal cord. It may also reduce pain in patients by inhibiting the release of substance P in the spinal cord, as well.
[69] [70] Baclofen withdrawal can be more intense if it is administered intrathecally or for long periods of time. If baclofen or phenibut is used for long periods of time, it can resemble intense benzodiazepine, GHB, or alcohol withdrawal. To minimize withdrawal symptoms, baclofen or phenibut should be tapered down slowly.
Taking digoxin, a medication typically prescribed for congestive heart failure. Using gabapentin, an anticonvulsant. Taking baclofen, a muscle relaxant. Using terbutaline, a bronchodilator.
Fresh bacon should have a firm, slightly greasy feel, and bacon that feels slimy or sticky to the touch is no longer safe to eat. The presence of a slimy coating indicates that bacteria has begun ...
The clinical effectiveness of methocarbamol compared to other muscle relaxants is not well known. [13] One trial of methocarbamol versus cyclobenzaprine, a well-studied muscle relaxant, in those with localized muscle spasm found there were no significant differences in their effects on muscle spasm, limitation of motion, or limitation of daily activities.
Shenandoah National Park, Virginia. Seventy-five miles from Washington D.C., and about 100 miles from Richmond, Virginia, Shenandoah National Park is a leisurely road trip to take in the state's ...