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There is also a version called GamEvac which is a homologous Ad5-vectored vaccine. [1] GamEvac-Combi was developed by Gamaleya Research Institute of Epidemiology and Microbiology . As of 2015 [update] the vaccine has been licensed in Russia for emergency use, on the basis of Phase 1 and Phase 2 clinical trials.
The vaccine is based on the newly published genetic sequence [69] of the 2014 Guinea Ebola (Makona) strain that is responsible for the 2014 Ebola disease epidemic in West Africa. In animal studies, a useful immune response was induced and was found to be enhanced ten to a hundred-fold by the company's "Matrix-M" immunologic adjuvant .
In April 2019, following a large-scale ring-vaccination scheme in the DRC outbreak, the WHO published the preliminary results of its research, in association with the DRC's Institut National pour la Recherche Biomedicale, into the effectiveness of the ring vaccination program, stating that the rVSV-ZEBOV-GP vaccine had been 97.5% effective at stopping Ebola transmission, relative to no ...
A stockpile of half-a-million Ebola vaccine doses was established by Gavi and other global health partners in 2019 for use in outbreaks of haemorrhagic fever, which has an average fatality rate of ...
The Ebola virus devastated west Africa in 2014, claiming over 11,000 lives in Sierra Leone, Liberia and Guinea. It was the largest Ebola outbreak since the virus had first been discovered in the ...
Up to an additional US$90 million could be used to support countries to introduce the vaccines and to rebuild and restore immunisation services for all vaccines in Ebola-affected countries. [ 186 ] In December 2016, it was announced that an experimental Ebola vaccine produced by Merck was found to be "highly protective" against the virus after ...
No licensed vaccines exist, though a vaccine by Moderna, in coordination with the U.S. National Institute of Allergy and Infectious Diseases Vaccine Research Center, is being evaluated. Rift ...
The 2018 Équateur province Ebola outbreak occurred in the north-west of the Democratic Republic of the Congo (DRC) from May to July 2018. It was contained entirely within Équateur province, and was the first time that vaccination with the rVSV-ZEBOV Ebola vaccine had been attempted in the early stages of an Ebola outbreak, [6] with a total of 3,481 people vaccinated.