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It has a slower onset and a longer-lasting effect compared with other alpha blockers. It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia, [2] although it is currently seldom used for that indication due to unfavourable side effects. It has been used in the treatment of hypoplastic left heart syndrome. [3]
Here decarbonylation accompanies the preparation of cyclopentadienyliron dicarbonyl dimer: 2 Fe(CO) 5 + C 10 H 12 → (η 5 −C 5 H 5) 2 Fe 2 (CO) 4 + 6 CO + H 2. Decarbonylation can be induced photochemically as well as using reagents such as trimethylamine N-oxide: Me 3 NO + L + Fe(CO) 5 → Me 3 N + CO 2 + LFe(CO) 4
Thus, synthesis of benzaldehyde through the Friedel–Crafts pathway requires that formyl chloride be synthesized in situ. This is accomplished by the Gattermann-Koch reaction, accomplished by treating benzene with carbon monoxide and hydrogen chloride under high pressure, catalyzed by a mixture of aluminium chloride and cuprous chloride ...
Upon heating, 2,4,6-trinitrobenzoic acid undergoes decarboxylation to give 1,3,5-trinitrobenzene. [4] Reduction with tin gives 2,4,6-triaminobenzenoic acid, a precursor to phloroglucinol (1,3,5-trihydroxybenzene).
The decarboxylation of this compound by heat is essential for the psychoactive effect of smoked cannabis, and depends on conversion of the enol to a keto group when the alpha carbon is protonated. Upon heating, Δ9-tetrahydrocannabinolic acid decarboxylates to give the psychoactive compound Δ9- Tetrahydrocannabinol . [ 13 ]
It is one of three isomers of benzene dicarbaldehyde, related to phthalic acid. This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids. OPA dissolves in water solution at pH < 11.5. Its solutions degrade upon UV illumination and exposure to air.
The alpha-ketol rearrangement is an interconversion of a hydroxyl alpha to a carbonyl to the complementary carbonyl and hydroxyl groups, with migration of a substituent. It is mechanistically equivalent to the benzyllic acid rearrangement at the point after the nucleophile attacks the 1,2-dicarbonyl.
The reaction product is a derivative of benzene. Scheme 1. Bergman cyclization. The reaction proceeds by a thermal reaction or pyrolysis (above 200 °C) forming a short-lived and very reactive para-benzyne biradical species. It will react with any hydrogen donor such as 1,4-cyclohexadiene which converts to benzene.