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Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is encoded by the DIO3 gene. [ 5 ] [ 6 ] This enzyme catalyses the following chemical reaction
Iodothyronine deiodinases (EC 1.21.99.4 and EC 1.21.99.3) are a subfamily of deiodinase enzymes important in the activation and deactivation of thyroid hormones. Thyroxine (T 4), the precursor of 3,5,3'-triiodothyronine (T 3) is transformed into T 3 by deiodinase activity.
Three related isoforms, deiodinase type I, II, and III, contribute to activation and inactivation of the initially released hormone precursor T 4 into T 3 (triiodothyronine) or rT 3 (reverse triiodothyronine) in target cells. The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions ...
The decreased clearance is possibly from lower thyroxine 5-deiodinase activity in the peripheral tissue or decreased liver uptake of rT 3. [2] In addition, increased rT 3 concentrations result from upregulated thyroxine 5-deiodinase activity in critical illness, starvation and fetal life.
Thyroxine is believed to be a prohormone and a reservoir for the most active and main thyroid hormone T 3. [52] T 4 is converted as required in the tissues by iodothyronine deiodinase. [53] Deficiency of deiodinase can mimic hypothyroidism due to iodine deficiency. [54] T 3 is more active than T 4, [55] though it is present in less quantity ...
Thyroxine deiodinase may refer to: Iodothyronine deiodinase; Thyroxine 5-deiodinase This page was last edited on 20 October 2024, at 09:40 (UTC). Text is available ...