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  2. Dynamic kinetic resolution in asymmetric synthesis - Wikipedia

    en.wikipedia.org/wiki/Dynamic_Kinetic_Resolution...

    Asymmetric synthesis has become a much explored field due to the challenge of creating a compound with a single 3D structure. [1] Even more challenging is the ability to take a racemic mixture and have only one chiral product left after a reaction. One method that has become an exceedingly useful tool is dynamic kinetic resolution (DKR).

  3. Enantioselective synthesis - Wikipedia

    en.wikipedia.org/wiki/Enantioselective_synthesis

    Enantioselective synthesis, also called asymmetric synthesis, [1] is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric ( enantiomeric or diastereomeric ) products in unequal ...

  4. Depletion force - Wikipedia

    en.wikipedia.org/wiki/Depletion_force

    Atomic force microscopy (AFM) is commonly used to directly measure the magnitude of depletion forces. This method uses the deflection of a very small cantilever contacting a sample which is measured by a laser. The force required to cause a certain amount of beam deflection can be determined from the change in angle of the laser.

  5. Non-linear effects - Wikipedia

    en.wikipedia.org/wiki/Non-linear_effects

    It is often referred to as asymmetric amplification, a term coined by Oguni and co-workers. [4] An example of a positive non-linear effect is observed in the case of Sharpless epoxidation with the substrate geraniol.In all cases of chemical reactivity exhibiting (+)-NLE, there is an innate tradeoff between overall reaction rate and ...

  6. Kinetic resolution - Wikipedia

    en.wikipedia.org/wiki/Kinetic_resolution

    Kinetic resolution is a possible method for irreversibly differentiating a pair of enantiomers due to (potentially) different activation energies. While both enantiomers are at the same Gibbs free energy level by definition, and the products of the reaction with both enantiomers are also at equal levels, the Δ G ‡ {\displaystyle \Delta G ...

  7. Stopped-flow - Wikipedia

    en.wikipedia.org/wiki/Stopped-flow

    The stopped-flow method evolved from the continuous-flow technique developed by Hamilton Hartridge and Francis Roughton [7] to study the binding of oxygen to hemoglobin. In the continuous-flow system, the reaction mixture was passed through a long tube, past an observation system (a simple colorimeter in 1923), and then discarded as waste.

  8. Chiral auxiliary - Wikipedia

    en.wikipedia.org/wiki/Chiral_auxiliary

    Chiral auxiliaries are incorporated into synthetic routes to control the absolute configuration of stereogenic centers. David A. Evans' synthesis of the macrolide cytovaricin, considered a classic, utilizes oxazolidinone chiral auxiliaries for one asymmetric alkylation reaction and four asymmetric aldol reactions, setting the absolute stereochemistry of nine stereocenters.

  9. Asymmetric flow field flow fractionation - Wikipedia

    en.wikipedia.org/wiki/Asymmetric_flow_field_flow...

    The rate of laminar flow within the channel is not uniform. It travels in a parabolic pattern with the speed of the flow increasing towards the center of the channel and decreasing towards the sides. Therefore, the rate at which particles will be carried through will depend on their position within the channel.

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