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In drug-induced nonautoimmune hemolytic anemia, red blood cells (RBC) are destroyed from various non-immune mechanisms such as direct oxidative stress from certain drugs. [1] This is in contrast to drug-induced autoimmune hemolytic anemia where certain drugs result in the formation of antibodies against RBCs, resulting in hemolysis.
In some cases, a drug can cause the immune system to mistakenly think the body's own red blood cells are dangerous, foreign substances. Antibodies then develop against the red blood cells. The antibodies attach to red blood cells and cause them to break down too early. It is known that more than 150 drugs can cause this type of hemolytic anemia ...
Areas of hair loss, usually on the scalp [7] Usual onset: Childhood [7] Causes: Autoimmune [7] Risk factors: Family history, female sex, rheumatoid arthritis, type 1 diabetes, celiac disease [7] [8] [9] Differential diagnosis: Trichotillomania, alopecia mucinosa, postpartum alopecia [1] Treatment: Sunscreen, head coverings to protect from sun ...
Alopecia mucinosa, also known as Follicular mucinosis, Mucinosis follicularis, Pinkus' follicular mucinosis, and Pinkus' follicular mucinosis–benign primary form, is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp, neck and face.
There are a number of conditions that may cause non scarring hair loss and the first step is to determine the pattern: focal or diffuse. [3] The next step is to identify if the hair loss is scarring or non scarring. A history and physical examination is necessary as this will provide clues to the ultimate diagnosis. It is essential to ask about ...
Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder which occurs when antibodies directed against the person's own red blood cells (RBCs) cause them to burst , leading to an insufficient number of oxygen-carrying red blood cells in circulation . The lifetime of the RBCs is reduced from the normal 100–120 days to just a few days in ...
Alopecia totalis is the loss of all hair on the head and face.Its causes are unclear, but believed to be autoimmune.Research suggests there may be a genetic component linked to developing alopecia totalis; the presence of DRB1*0401 and DQB1*0301, both of which are human leukocyte antigens (HLA), were found to be associated with long-standing alopecia totalis.
However, the main side effect is increased risk of cutaneous atrophy at the site of treatment; [8] folliculitis is also an occasional complication. [9] Janus kinase inhibitors, previously used in the treatment of cancer and other diseases, such as arthritis, have successfully shown to be effective in the initial trials of treatment for alopecia ...