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An HPV infection is caused by the human papillomavirus, a DNA virus from the papillomavirus family. [8] [9] Over 200 types have been described. [10] An individual can become infected with more than one type of HPV, [11] and the disease is only known to affect humans.
Cervicitis is inflammation of the uterine cervix. [1] Cervicitis in women has many features in common with urethritis in men and many cases are caused by sexually transmitted infections. Non-infectious causes of cervicitis can include intrauterine devices, contraceptive diaphragms, and allergic reactions to spermicides or latex condoms. [2]
The infection can spread to the upper genital tract in women, causing pelvic inflammatory disease, which may result in future infertility or ectopic pregnancy. [2] Chlamydia infections can occur in other areas besides the genitals, including the anus, eyes, throat, and lymph nodes.
Without treatment, about 10 percent of those with a chlamydial infection and 40 percent of those with a gonorrhea infection will develop PID. [2] [10] Risk factors are generally similar to those of sexually transmitted infections and include a high number of sexual partners and drug use. [2] Vaginal douching may also increase the risk. [2]
ICD-10 is the 10th revision of the International Classification of Diseases (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. [1]
The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
ThinPrep pap smear with group of normal cervical cells on left and HPV-infected cells showing features typical of koilocytes: enlarged (x2 or x3) nuclei and hyperchromasia. A koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus (HPV). [1]
It is usually a non-pathological symptom secondary to inflammatory conditions of the vagina or cervix. [5] Leukorrhea can be confirmed by finding >10 WBC per high-power field under a microscope when examining vaginal fluid. [6] Vaginal discharge is normal, and causes of change in discharge include infection, malignancy, and hormonal changes.