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[16]: 1098 Synovitis can lead to tethering of tissue with loss of movement and erosion of the joint surface causing deformity and loss of function. [2] The fibroblast-like synoviocytes (FLS), highly specialized mesenchymal cells found in the synovial membrane, have an active and prominent role in these pathogenic processes of the rheumatic joints.
Rheumatism [2] / ˈ r uː m ə t ɪ z əm / or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. [3] Rheumatism does not designate any specific disorder, but covers at least 200 different conditions, including arthritis and "non-articular rheumatism", also known as "regional pain syndrome" or "soft tissue rheumatism".
The inflammatory mediators of RA including cytokines, growth factors, metalloproteinases destroy articular cartilage, subchondral bone, tendons and ligaments.Destructive synovitis leads to bone erosion and causes the ligaments of the spine to become too laxed (loose), eventually resulting in cervical spinal instability (loose neck bones).
Some of these are very serious diseases that can be difficult to diagnose and treat. They treat soft tissue problems related to the musculoskeletal system and sports-related soft tissue disorders. Pediatric rheumatologist: A pediatric rheumatologist is a pediatrician who specializes in the treatment of children with rheumatic disease. [4]
In all subtypes of spondyloarthritis, inflammatory back pain and/or asymmetrical arthritis, mainly affecting the lower limbs, are the most common symptoms. [9] Another characteristic is enthesitis, which is inflammation at the locations where ligaments, tendons, or joint capsules adhere to bone. [10] Sacroiliitis symptoms
Palindromic rheumatism (PR) is a syndrome characterised by recurrent, self-resolving inflammatory attacks in and around the joints , and consists of arthritis or periarticular soft tissue inflammation. [1] The course is often acute onset, with sudden and rapidly developing attacks or flares.
Other rheumatological disorders that can cause the features typical for RS3PE include late onset (seronegative) rheumatoid arthritis, acute sarcoidosis, ankylosing spondylitis and other spondyloarthropathies such as psoriatic arthropathy, mixed connective tissue disease, chondrocalcinosis and arthropathy due to amyloidosis.
The occurrence of nodules in the lungs of miners exposed to silica dust was known as Caplan’s syndrome. [2] Rarely, the nodules occur at diverse sites on body (e.g., upper eyelid , distal region of the soles of the feet, vulva , and internally in the gallbladder , lung, heart valves , larynx , and spine ).