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Chromosomal reciprocal translocation of the 4th and 20th chromosome. In genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal, and Robertsonian translocation.
A Robertsonian translocation. The short arms of the chromosomes (shown on right) are often lost . Robertsonian translocation (ROB) is a chromosomal abnormality where the entire long arms of two different chromosomes become fused to each other. It is the most common form of chromosomal translocation in humans, affecting 1 out of every 1,000 ...
In the human genome, C-myc is located on chromosome 8 and is believed to regulate expression of 15% of all genes [7] through binding on enhancer box sequences . In addition to its role as a classical transcription factor, N-myc may recruit histone acetyltransferases (HATs). This allows it to regulate global chromatin structure via histone ...
Since 2010, scientists have known that the Y chromosome is rapidly evolving in humans, but a new study shows that the same can be said across all Great Apes—the closest relatives to humans.
This allowed chromosome pairs of otherwise equal size to be differentiated by distinct horizontal banding patterns. Banding patterns are now used to elucidate the breakpoints and constituent chromosomes involved in chromosome translocations. Deletions and inversions within an individual chromosome can also be identified and described more ...
Balancer chromosomes were first used in the fruit fly by Hermann Muller, who pioneered the use of radiation for organismal mutagenesis. [2]In the modern usage of balancer chromosomes, random mutations are first induced by exposing living organisms with otherwise normal chromosomes to substances which cause DNA damage; in flies and nematodes, this usually occurs by feeding larvae ethyl ...
Possessing chromosomes of varying shapes is generally the result of a chromosomal translocation or chromosomal inversion. In a translocation, genetic material is transferred from one chromosome to another, either symmetrically or asymmetrically (a Robertsonian translocation). In an inversion, a segment of a chromosome is flipped end-for-end.
t(11;14) is a chromosomal translocation which essentially always involves the immunoglobulin heavy locus, also known as IGH in the q32 region of chromosome 14, as well as cyclin D1 which is located in the q13 of chromosome 11 . [2] Specifically, the translocation is at t(11;14)(q13;q32). [3] [4]