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A dorsal root ganglion (or spinal ganglion; also known as a posterior root ganglion [1]) is a cluster of neurons (a ganglion) in a dorsal root of a spinal nerve. The cell bodies of sensory neurons known as first-order neurons are located in the dorsal root ganglia. [2] The axons of dorsal root ganglion neurons are known as afferents.
The root emerges from the posterior part of the spinal cord and travels to the dorsal root ganglion. The dorsal root ganglia contain the pseudo-unipolar cell bodies of the nerve fibres which travel from the ganglia through the root into the spinal cord. The lateral division of the dorsal root contains lightly myelinated and unmyelinated fibres ...
These rami also contain general visceral afferent fibers (sensory from the organs) whose primary cell bodies reside dorsal root ganglia (which then synapse in the dorsal horn). The preganglionic sympathetic fibers will enter into the sympathetic trunk and either synapse at the ganglion on the same level, or travel up or down the sympathetic ...
The body is situated in the dorsal root ganglion, with one axon traveling peripherally to tissue, and one traveling into the dorsal column. On the right is a bipolar neuron. When an action potential is generated by a mechanoreceptor in the tissue, the action potential will travel along the peripheral axon of the first-order neuron.
The GVA pathway then diverges from the sympathetic efferent pathway, which follows the ventral root into the spinal column, by following the dorsal root into the dorsal root ganglion, where the cell body of the visceral afferent nerve is located. [5]
Opposing gradients of such morphogens as BMP and SHH form different domains of dividing cells along the dorsal ventral axis. [15] Dorsal root ganglion neurons differentiate from neural crest progenitors. As the dorsal and ventral column cells proliferate, the lumen of the neural tube narrows to form the small central canal of the spinal cord. [16]
The ventral rami supply the antero-lateral parts of the trunk and the limbs. They are mainly larger than the dorsal rami. Shortly after a spinal nerve exits the intervertebral foramen, it branches into the dorsal ramus, the ventral ramus, and the ramus communicans. Each of these three structures carries both sensory and motor information.
A dorsal root ganglion (DRG) from a chicken embryo (around stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Note the axons growing out of the ganglion. A ganglion (pl.: ganglia) is a group of neuron cell bodies in the peripheral nervous system.