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ETS1 binds with DNA-dependent protein kinase (DNA-PK) [where the DNA-PK complex is made up of DNA-PKcs and DNA repair Ku (protein), and where Ku itself is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5)]. [17] ETS1 interaction with DNA-PK phosphorylates ETS1. [17] Such phosphorylation of ETS1 alters its target gene repertoire. [18]
For example, the ERG ETS transcription factor is fused to the EWS gene, resulting in a condition called Ewing's sarcoma. [6] The fusion of TEL to the JAK2 protein results in early pre-B acute lymphoid leukaemia. [7] ERG and ETV1 are known gene fusions found in prostate cancer. [8]
A hard disk drive failure occurs when a hard disk drive malfunctions and the stored information cannot be accessed with a properly configured computer. A hard disk failure may occur in the course of normal operation, or due to an external factor such as exposure to fire or water or high magnetic fields , or suffering a sharp impact or ...
The fastest high-end server drives of 2010 had a seek time around 4 ms. [14] Some mobile devices have 15 ms drives, with the most common mobile drives at about 12 ms [15] and the most common desktop drives typically being around 9 ms. Two other less commonly referenced seek measurements are track-to-track and full stroke.
This technique when combined with high throughput sequencing is known as ChIP-Seq and when combined with microarrays it is known as ChIP-chip. Yeast one-hybrid System (Y1H) is used to identify which protein binds to a particular DNA fragment. Bacterial one-hybrid system (B1H) is used to identify which protein binds to a particular DNA fragment.
If the actual size of the disk exceeds the maximum partition size representable using the legacy 32-bit LBA entries in the MBR partition table, the recorded size of this partition is clipped at the maximum, thereby ignoring the rest of the disk. This amounts to a maximum reported size of 2 TiB, assuming a disk with 512 bytes per sector (see 512e).
Euro Truck Simulator (known as Big Rig Europe in North America) is a 2008 truck simulation game developed and published by SCS Software.The game is set in a scaled-down rendition of Europe, from the United Kingdom and Portugal to Poland and the Czech Republic, where players drive a variety of semi-trucks and trailers across the continent, visiting the continent's major cities, picking up and ...
High density (HD) 3½-inch disks switch to a cobalt disk coating, just as with 5¼-inch HD disks. Drives use 700-oersted write heads for a density of 17,434 bpi. Extra-high density (ED) doubles the capacity over HD by using a barium ferrite coating and a special write head that allows the use of perpendicular recording. [1] [2]