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The Database of Interacting Proteins (DIP) is a biological database which catalogs experimentally determined interactions between proteins. [ 2 ] [ 3 ] It combines information from a variety of sources to create a single, consistent set of protein–protein interactions.
Protein-protein and other molecular interactions Database of Interacting Proteins: Univ. of California: Protein-protein and other molecular interactions IntAct [21] EMBL-EBI: open-source database for molecular interactions Protein-protein and other molecular interactions String: an open source molecular interaction database to study ...
The Biological General Repository for Interaction Datasets (BioGRID) is a curated biological database of protein-protein interactions, genetic interactions, chemical interactions, and post-translational modifications created in 2003 (originally referred to as simply the General Repository for Interaction Datasets (GRID) [2] by Mike Tyers, Bobby-Joe Breitkreutz, and Chris Stark at the Lunenfeld ...
Protein annotation information that is catalogued was derived through manual curation using published literature by expert biologists and through bioinformatics analyses of the protein sequence. The protein–protein interaction and subcellular localization data from HPRD have been used to develop a human protein interaction network. [2]
For example, the primary database IntAct has 572,063 interactions, [64] the meta-database APID has 678,000 interactions, [65] and the predictive database STRING has 25,914,693 interactions. [66] However, it is important to note that some of the interactions in the STRING database are only predicted by computational methods such as Genomic ...
Protein–protein interaction networks are an important ingredient for the system-level understanding of cellular processes. Such networks can be used for filtering and assessing functional genomics data and for providing an intuitive platform for annotating structural, functional and evolutionary properties of proteins.
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