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Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. [7] It is generally recommended only for people who cannot take allopurinol. [8] [9] It is taken by mouth. [7] Common side effects include liver problems, nausea, joint pain, and a rash. [7]
This category reflects the organization of Anatomical Therapeutic Chemical Classification System code M04. Generally, drugs outlined within the ATC code M04 should be included in this category. Please see WP:PHARM:CAT for more information.
[62] [63] A number of other medications may occasionally be considered to prevent further episodes of gout, including probenecid, febuxostat, benzbromarone, and colchicine. [12] [64] [65] Long term medications are not recommended until a person has had two attacks of gout, [20] unless destructive joint changes, tophi, or urate nephropathy exist ...
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]
Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...
Phenazopyridine does not treat infections or injury; it is only used for symptom relief. [3] [4] It is recommended that it be used for no longer than the first two days of antibacterial treatment as longer treatment may mask symptoms. [4] Phenazopyridine is also prescribed for other cases requiring relief from irritation or discomfort during ...
Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine.It is primarily used in treating gout and hyperuricemia.
Cilostazol is metabolized by CYP3A4 and CYP2C19, two isoenzymes of the cytochrome P450 system. Drugs that inhibit CYP3A4, such as itraconazole, erythromycin, ketoconazole, and diltiazem, are known to interact with cilostazol. The proton pump inhibitor omeprazole, an inhibitor of CYP2C19, increases exposure to the active metabolite of cilostazol.