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ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). [5] [6] [7] HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family ...
In the EMILIA clinical trial [15] of women with advanced HER2 positive breast cancer who were already resistant to trastuzumab alone, it improved median overall survival by 5.8 months (30.9 months vs. 25.1 months) compared to the combination of lapatinib and capecitabine. [14]
In early-stage HER2-positive breast cancer, trastuzumab-containing regimens improved overall survival (Hazard ratio (HR) = 0.66) and disease-free survival (HR = 0.60). [38] Increased risk of heart failure (RR = 5.11) and decline in left ventricular ejection fraction ( relative risk RR = 1.83) were seen in these trials as well. [ 38 ]
Sea sponge aquaculture is the process of farming sea sponges under controlled conditions. It has been conducted in the world's oceans for centuries using a number of aquaculture techniques. There are many factors such as light, salinity, pH, dissolved oxygen and the accumulation of waste products that influence the growth rate of sponges. The ...
When food availability is low, all groups containing transgenic salmon experience population crashes or complete extinctions, whereas groups containing only non-transgenic salmon have good (72%) survival rates. [58] This has led to the suggestion that these GM fish will survive better than the wild-type when conditions are very poor. [28] [59]
First, at very low population sizes, the value of is small, so the population growth rate is approximately equal to , meaning the population is growing exponentially at a rate r (the intrinsic rate of population increase). Despite this, the population growth rate is very low (low values on the y-axis of figure 2) because, even though each ...
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