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Naloxegol (INN; PEGylated naloxol; [4] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation. [5] It was approved in 2014 in adult patients with chronic, non-cancer pain. [6]
Methylnaltrexone (MNTX, brand name Relistor), used in form of methylnaltrexone bromide (INN, USAN, BAN), is a medication that acts as a peripherally acting μ-opioid receptor antagonist that acts to reverse some of the side effects of opioid drugs such as constipation without significantly affecting pain relief or precipitating withdrawals.
Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon ...
Constipation can be the result of dehydration, irritable bowel syndrome (IBS), poor diet, and taking various medications, says Jean Fox, MD, a gastroenterologist at Mayo Clinic. Pelvic floor ...
Crohn's disease – also known as regional enteritis, it can occur along any surface of the gastrointestinal tract. The most common location for Crohn's disease to manifest, with or without the involvement of the colon or other parts of the GI tract, is in the terminal ileum (the final segment of the small intestine). [5]
Ileitis is an inflammation of the ileum, a portion of the small intestine. Mycobacterium tuberculosis infection may mimic Crohn's disease Ileitis. [1] Ileitis may be linked to a broad range of illnesses, such as sarcoidosis, amyloidosis, ischemia, neoplasms, spondyloarthropathies, vasculitides, drug-related conditions, and eosinophilic ...