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  2. NK-92 - Wikipedia

    en.wikipedia.org/wiki/NK-92

    The NK-92 cell line is an immortalised cell line that has the characteristics of a type of immune cell found in human blood called ’natural killer’ (NK) cells. Blood NK cells and NK-92 cells recognize and attack cancer cells as well as cells that have been infected with a virus, bacteria, or fungus. [1]

  3. Natural killer cell - Wikipedia

    en.wikipedia.org/wiki/Natural_killer_cell

    A more efficient way to obtain high numbers of NK cells is to expand NK-92 cells, an NK cell line with all the characteristics of highly active blood Natural Killer (NK) cells but with much broader and higher cytotoxicity. NK-92 cells grow continuously in culture and can be expanded to clinical-grade numbers in bags or bioreactors. [56]

  4. Innate immune system - Wikipedia

    en.wikipedia.org/wiki/Innate_immune_system

    Normal body cells are not recognized and attacked by NK cells because they express intact self MHC antigens. Those MHC antigens are recognized by killer cell immunoglobulin receptors (KIR) that slow the reaction of NK cells. The NK-92 cell line does not express KIR and is developed for tumor therapy. [11] [12] [13] [14]

  5. Killer-cell immunoglobulin-like receptor - Wikipedia

    en.wikipedia.org/wiki/Killer-cell_immunoglobulin...

    Natural killer (NK) cells are a type of lymphocyte cell involved in the innate immune system's response to viral infection and tumor transformation of host cells. [20] [7] Like T cells, NK cells have many qualities characteristic of the adaptive immune system, including the production of “memory” cells that persist following encounter with antigens and the ability to create a secondary ...

  6. NKG2 - Wikipedia

    en.wikipedia.org/wiki/NKG2

    In both humans and mice, genes encoding the NKG2 family are clustered – in human genome on chromosome 12, in mouse on chromosome 6. [2] They are generally expressed on NK cells and a subset of CD8 + T cells, although the expression of NKG2D was also confirmed on γδ T cells, NKT cells, and even on some subsets of CD4 + T cells or myeloid cells.

  7. Cellular senescence - Wikipedia

    en.wikipedia.org/wiki/Cellular_senescence

    Natural killer cells (NK cells) and macrophages play a major role in clearance of senescent cells. [65] Natural killer cells directly kill senescent cells, and produce cytokines which activate macrophages which remove senescent cells. [65] Senescent cells can be phagocytized by neutrophils as well as by macrophages. [66]

  8. Null cell - Wikipedia

    en.wikipedia.org/wiki/Null_cell

    Null cells, a subset of large circulating white blood cells, mimic the appearance of T or B lymphocytes but do not possess their defining surface receptors. Predominantly, these include natural killer cells (NK cells), with a lesser portion being hematopoietic stem cells traversing freely within the bloodstream .

  9. Killer activation receptor - Wikipedia

    en.wikipedia.org/wiki/Killer_activation_receptor

    In cancers, a Killer Activation Receptor (KAR), located on the surface of the NK cell, binds to certain molecules which only appear on cells that are undergoing stress situations. In humans, this KAR is called NKG2D and the molecules it recognizes MICA and MICB. This binding provides a signal which induces the NK cell to kill the target cell. [9]