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Satellite cells have a crucial role in muscle regeneration due to their ability to proliferate, differentiate, and self-renew. Prior to a severe injury to the muscle, satellite cells are in a dormant state. Slight proliferation can occur in times of light injuries but major injuries require greater numbers of satellite cells to activate.
As the muscle completes repair Wnt7b and Wnt3a are increased as well. This patterning of Wnt signalling expression in muscle cell repair induces the differentiation of the progenitor cells, which reduces the number of available satellite cells. Wnt plays a crucial role in satellite cell regulation and skeletal muscle aging and also regeneration.
Wagers researches intrinsic and extrinsic regulators of stem cell function and how stem cells impact tissue regeneration and aging. She has demonstrated that transplantation of satellite cells into injured, diseased, or aged muscle can lead to cell engraftment, in some cases restoring muscle function.
Although muscle contains a stem cell population called satellite cells that are capable of regenerating small muscle injuries, muscle damage in VML is so extensive that it overwhelms muscle's natural regenerative capabilities. Currently VML is treated through an autologous muscle flap or graft but there are various problems associated with this ...
This disrupts the proper linkage between the basal lamina and muscle cell membrane. Consequently, the contractile mechanism is disrupted. Integrin-α7β1 is important to satellite cell function, and myoblast adhesion and viability. Thusly, integrin-α7β1is an important contributor to skeletal muscle regeneration.
Helen Blau FRS is a cell biologist and stem cell researcher famous for her work on muscle diseases, regeneration and aging.She is the Donald E. and Delia B. Baxter Foundation Professor and the Director of the Baxter Laboratory for Stem Cell Biology at Stanford University. [1]
They are crucial for the repair of muscle, but have a very limited ability to replicate. Activated by stimuli such as injury or high mechanical load, satellite cells are required for muscle regeneration in adult organisms. [4] In addition, satellite cells have the capability to also differentiate into bone or fat.
When these cells were combined with satellite cells from wt P10 mice and cultured, the two cell types were able to coalesce and regenerate skeletal muscle in vivo. [3] Experiments were also conducted using quail dorsal aorta cells transplanted into the wings of chick embryos.