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A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
Glucosamine is often sold in combination with other supplements such as chondroitin sulfate and methylsulfonylmethane. [citation needed] Glucosamine, along with commonly used chondroitin, is not routinely prescribed to treat people who have symptomatic osteoarthritis of the knee, as there is insufficient evidence that this treatment is helpful ...
Distinguished from chondroitin sulfate by the presence of iduronic acid, although some hexuronic acid monosaccharides may be glucuronic acid. [16] Keratan sulfate: Gal or Gal(6S) GlcNAc or GlcNAc(6S)-Gal(6S)β1-4GlcNAc(6S)β1-3: Keratan sulfate type II may be fucosylated. [21] Heparin: GlcUA or IdoUA(2S) GlcNAc or GlcNS or GlcNAc(6S) or GlcNS(6S)
General Glucosamine and Chondroitin Sulfate information at Arthritis Foundation "Product Review: Joint Supplements (Glucosamine, Chondroitin, and MSM)" Summary of a Consumer Labs test of the actual composition of these supplements at consumerlabs.com
Rhino pills and other non-prescription supplements aren’t regulated by the U.S. Food and Drug Administration (FDA) like medications are, and there’s rarely much science to back their claims.
The effectiveness of glucosamine is controversial. [155] Reviews have found it to be equal to [156] [157] or slightly better than placebo. [158] [159] A difference may exist between glucosamine sulfate and glucosamine hydrochloride, with glucosamine sulfate showing a benefit and glucosamine hydrochloride not. [160]