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Very rare adverse effects of olanzapine (that are necessarily causally related), occurring less than 0.01%, include: Agranulocytosis, a potentially fatal drop in white blood cell count, basically an exaggerated form of leukopaenia. Thrombocytopaenia. A drop in blood platelet counts which are involved in blood clotting.
The principal side effect of olanzapine is weight gain, which may be profound in some cases and/or associated with derangement in blood-lipid and blood-sugar profiles (see section metabolic effects). A 2013 meta-analysis of the efficacy and tolerance of 15 antipsychotic drugs (APDs) found that it had the highest propensity for causing weight ...
Note: "Notable" is to mean side-effects that are particularly unique to the antipsychotic drug in question. For example, clozapine is notorious for its ability to cause agranulocytosis. If data on the propensity of a particular drug to cause a particular AE is unavailable an estimation is substituted based on the pharmacologic profile of the drug.
Olanzapine/fluoxetine could produce a severe allergic reaction and should not be used if the patient has previously experienced an allergic reaction to either fluoxetine or olanzapine. [9] Olanzapine is correlated with an increase in blood sugar. Patients with diabetes, or those at risk for developing it, require careful monitoring. [9] In rare ...
Serious side effects may include mania, low white blood cell count, and increased suicide among children. [12] Withdrawal symptoms may occur with stopping. [ 16 ] It is not recommended together with a monoamine oxidase inhibitor , [ 12 ] although evidence supporting the danger of this combination has been challenged. [ 17 ]
Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [7] It is used primarily to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
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