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Serious side effects may include angioedema, low blood sugar, kidney problems, pancreatitis, and joint pain. [8] Whether use in pregnancy or breastfeeding is safe is unclear. [ 10 ] It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decreasing the production of glucagon by the pancreas.
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
In type 1 diabetes, there is a lower total level of insulin to control blood glucose, due to an autoimmune-induced loss of insulin-producing beta cells in the pancreas. [ 12 ] [ 13 ] Diagnosis of diabetes is by blood tests such as fasting plasma glucose , oral glucose tolerance test , or glycated hemoglobin (A1c).
Apples. The original source of sweetness for many of the early settlers in the United States, the sugar from an apple comes with a healthy dose of fiber.
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When you eat a meal, your blood sugar levels rise, and your body releases the hormone insulin in response. Insulin helps move that sugar from the blood into the cells, where it can be used for energy.