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Tegafur/uracil (abbreviation: UFT [1]) is a chemotherapy drug combination used in the treatment of cancer, primarily bowel cancer. UFT is an oral formulation combining uracil (a competitive inhibitor of dihydropyrimidine dehydrogenase ), and tegafur (a bioavailable 5-fluorouracil (5-FU) prodrug ) in a 4:1 molar ratio.
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil . When metabolised, it becomes 5-FU.
Tegafur/gimeracil/oteracil, sold under the brand name Teysuno among others is a fixed-dose combination medication used for the treatment of advanced gastric cancer when used in combination with cisplatin, [3] and also for the treatment of head and neck cancer, colorectal cancer, non–small-cell lung, breast, pancreatic, and biliary tract cancers.
1281 12825 Ensembl ENSG00000168542 ENSMUSG00000026043 UniProt P02461 P08121 RefSeq (mRNA) NM_000090 NM_001376916 NM_009930 RefSeq (protein) NP_000081 NP_034060 Location (UCSC) Chr 2: 188.97 – 189.01 Mb Chr 1: 45.35 – 45.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each ...
kidney - Bowman's capsule: Simple squamous - urinary kidney - Loop of Henle: Simple squamous - urinary kidney - descending thin limb: Simple squamous - urinary kidney - descending thick limb: simple cuboidal - urinary: renal pelvis: Transitional: urothelium: urinary: ureter: Transitional: urothelium: urinary: urinary bladder: Transitional ...
Uracil is also involved in the biosynthesis of polysaccharides and the transportation of sugars containing aldehydes. [22] Uracil is important for the detoxification of many carcinogens, for instance those found in tobacco smoke. [23] Uracil is also required to detoxify many drugs such as cannabinoids (THC) [24] and morphine (opioids). [25]
Uracil is one of the chemical building blocks for RNA, a molecule carrying directions for building and operating living organisms. Asteroid discovery suggests ingredients for life on Earth came ...
The extracellular fluids may be divided into three types: interstitial fluid in the "interstitial compartment" (surrounding tissue cells and bathing them in a solution of nutrients and other chemicals), blood plasma and lymph in the "intravascular compartment" (inside the blood vessels and lymphatic vessels), and small amounts of transcellular ...