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The last step in wet agglomeration is the final stabilization through drying. The agglomerated particles are dried to less than 5% water content, and cooled to below their glass transition temperature. [1] Wet agglomeration falls into two categories based on method of agitation: Mechanical mixing and pneumatic mixing.
The process can be very simple or very complex depending on the characteristics of the powders, the final objective of tablet making, and the equipment that is available. In the traditional wet granulation method the wet mass is forced through a sieve to produce wet granules which are subsequently dried.
Low shear wet granulation processes use very simple mixing equipment, and can take a considerable time to achieve a uniformly mixed state. High shear wet granulation processes use equipment that mixes the powder and liquid at a very fast rate, and thus speeds up the manufacturing process. Fluid bed granulation is a multiple-step wet granulation ...
This process is very important and needs experience to attain proper quality of granules before tableting. Quality of granule determines the smooth and trouble free process of tablets manufacturing. If granulation is not done in a proper manner, the resulting mixture may damage the tableting press.
In a granulation process, only the solid component of the mixture is required. Fluid is used only as an aid to processing. The high-shear mixer processes the solid material down to the desired particle size, and the mixture is then pumped to the drying bed where the fluid is removed, leaving behind the granular product.
Hence, it is called a wet process which usually covers pre-treatment, dyeing, printing, and finishing. [2] The wet process is usually done in the manufactured assembly of interlacing fibers, filaments and yarns, having a substantial surface (planar) area in relation to its thickness, and adequate mechanical strength giving it a cohesive structure.