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Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol. It can lead to cardiac failure , rhabdomyolysis , metabolic acidosis , and kidney failure , and is often fatal.
To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
However, Propofol can induce hypotension and bradycardia due to its calcium channel blocker and beta blocker properties. [15] At prolonged high Propofol dosages, it can induce Propofol infusion syndrome , characterized by acute refractory bradycardia leading to asystole accompanied by one of the following: rhabdomyolysis , acute fatty liver or ...
Pronator teres syndrome; Propofol infusion syndrome; Proteus syndrome; Proteus-like syndrome; Prune belly syndrome; Pseudo-Cushing's syndrome; Pseudodementia; Pseudoexfoliation syndrome; Psychoorganic syndrome; Puer aeternus; Pulmonary-renal syndrome; Purple glove syndrome; Purple urine bag syndrome
Propofol (di-isopropyl phenol) was synthesized by Glen and colleagues in the early 1970s, [7] but its first formulations were temporarily withdrawn due to a number of adverse reactions during clinical studies. [1] In 1983, a lipid emulsion formulation of propofol was available, which carried great potential during clinical trials. [8]
A new study finds that 9 out of 10 adults in the U.S. may have cardiovascular-kidney-metabolic (CKM) syndrome. The research found 90% of adults qualify for stage 1 or higher of this condition.
Etomidate [3] (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation [4] for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy.
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