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A sestamibi parathyroid scan is a procedure in nuclear medicine which is performed to localize parathyroid adenoma, which causes Hyperparathyroidism. [1] Adequate localization of parathyroid adenoma allows the surgeon to use a minimally invasive surgical approach.
A MIBI scan or sestamibi scan is now a common method of cardiac imaging. Technetium (99m Tc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow.
A sestamibi scan is a medical imaging technique using gamma rays from the radioactive decay of the manmade compound Technetium (99mTc) sestamibi to penetrate muscle and other tissue to view their condition and function. It may refer specifically to: MIBI scan, a type of cardiac imaging to assess the condition and function of the heart
These employ the same radioligands and have the same uses as SPECT scanning, but are able to provide even finer 3-D localization of high-uptake tissues, in cases where finer resolution is needed. An example is the sestamibi parathyroid scan which is performed using the 99m Tc radioligand sestamibi, and can be done in either SPECT or SPECT/CT ...
Micrograph of a parathyroid adenoma (left) and normal parathyroid gland (right). H&E stain.. Hyperparathyroidism is confirmed by blood tests such as calcium and PTH levels. A specific test for parathyroid adenoma is sestamibi parathyroid scintigraphy, often referred to as sestamibi scan or, more colloquially, MIBI scan.
The Sestamibi scan does not have high resolution. Neck ultrasound has higher resolution, but requires some expertise to perform. Ultrasound's shortcomings include: it cannot determine glandular function (normal vs. hyperfunctioning) or visualize unusual locations such as retropharyngeal or mediastinal.
[citation needed] Historically, technetium sestamibi scintigraphy was the main method used or this indication. [39] Recently 18F-fluorocholine PET/CT tend to be more and more performed due to excellent diagnostic performance. [40] [41]
Parathyroidectomy is the surgical removal of one or more of the (usually) four parathyroid glands.This procedure is used to remove an adenoma or hyperplasia of these glands when they are producing excessive parathyroid hormone (PTH): hyperparathyroidism.