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Ezetimibe/atorvastatin (trade names Liptruzet, Atozet) is a cholesterol lowering combination drug. In the United States, it was approved in May 2013, by the Food and Drug Administration for the treatment of elevated low-density lipoprotein (LDL) in patients with primary or mixed hyperlipidemia as adjunctive therapy to diet. [ 1 ]
The most important adverse side effects are muscle problems, an increased risk of diabetes mellitus, and increased liver enzymes in the blood due to liver damage. [5] [66] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. [35]
Most of Truvia's side effects are related to erythritol which is a sugar alcohol. Sugar alcohols are valuable as sweeteners since they cause little to no rise in blood glucose levels as sugar does. However, the downside to most sugar alcohols is their propensity to cause gastrointestinal side effects.
[99] [100] At high doses, statins have anti-inflammatory effects, incite reduction of the necrotic plaque core, and improve endothelial function, leading to plaque stabilization and, sometimes, plaque regression. [100] [99] There is a similar thought process with using high-dose atorvastatin as a form of secondary thrombotic stroke recurrence ...
Serious side effects may include anaphylaxis, liver problems, depression, and muscle breakdown. [4] [5] Use in pregnancy and breastfeeding is of unclear safety. [10] Ezetimibe works by decreasing cholesterol absorption in the intestines. [5] Ezetimibe was approved for medical use in the United States in 2002. [4] It is available as a generic ...
The exact cause of atherosclerosis is unknown and is proposed to be multifactorial. [1] Risk factors include abnormal cholesterol levels, elevated levels of inflammatory biomarkers, [12] high blood pressure, diabetes, smoking (both active and passive smoking), obesity, genetic factors, family history, lifestyle habits, and an unhealthy diet. [4]