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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
physical properties "PoLyInfo". 26,000 PPDB Pesticide Properties Database Agriculture & Environment Research Unit, University of Hertfordshire: Pesticides and their metabolites Chemical structure, physicochemical properties, human health and ecotoxicological data curated "PPDB". 2000 [10] Probes and Drugs ProCarDB
Although active transport is not modeled by the artificial PAMPA membrane, up to 95% of known drugs are absorbed by passive transport. [6] Some experts support a lower figure, so the amount is open to some interpretation. Microtiter plates with 96 wells can be used for the assay which increases the speed and lowers the per sample cost.
Therefore, the dose required to give a certain plasma concentration can be determined if the V D for that drug is known. The V D is not a physiological value; it is more a reflection of how a drug will distribute throughout the body depending on several physicochemical properties, e.g. solubility, charge, size, etc.
The specific processing of nanocapsules gives them unique properties in how they release drugs in certain situations. Generally, there are three physico-chemical release mechanisms that are used to release the drug or medicine from the polymeric shell of the nanocapsule. [4]
In drug design, [2] the purpose of exchanging one bioisostere for another is to enhance the desired biological or physical properties of a compound without making significant changes in chemical structure. The main use of this term and its techniques are related to pharmaceutical sciences.
dbAMP: [75] Provides an online platform for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data. dbAMP is an online resource that addresses various topics such as annotations of antimicrobial peptides (AMPs) including sequence information, antimicrobial activities, post ...
However, changing the structure of a molecule is less predictable than altering dissolution properties, since changes in chemical structure may affect the pharmacodynamic properties of a drug. The solubility and permeability of a drug candidate are important physicochemical properties the scientist wants to know as early as possible. [10]