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No animal species is known to be immune to the acute toxic effects of aflatoxins. Adult humans have a high tolerance for aflatoxin exposure and rarely succumb to acute aflatoxicosis, [31] but children are particularly affected, and their exposure can lead to stunted growth and delayed development, in addition to all the symptoms mentioned below ...
The effect of aflatoxin M 1 was much weaker than aflatoxin B 1 in producing liver cancer. The limited animal studies carried out to determine toxicity of aflatoxin M 1. Aflatoxin M 1 has toxic and carcinogenic properties. The toxicity of aflatoxin M 1 in ducklings and rats seems to be slightly less than that of aflatoxin B 1.
Aflatoxin B 1, the most toxic, is a potent carcinogen and has been directly correlated to adverse health effects, such as liver cancer, in many animal species. [11] Aflatoxins are largely associated with commodities produced in the tropics and subtropics, such as cotton, peanuts, spices, pistachios, and maize.
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The discovery of aflatoxins led to substantial changes in agricultural practices and regulations on how grains and legumes were grown, harvested, and stored. [21] The amount of aflatoxins produced by A. flavus is affected by environmental factors. If other competitive fungal organisms are present on host plants, aflatoxin production is low.
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Aflatoxin B 1 is an aflatoxin produced by Aspergillus flavus and A. parasiticus.It is a very potent carcinogen with a TD 50 3.2 μg/kg/day in rats. [4] This carcinogenic potency varies across species with some, such as rats and monkeys, seemingly much more susceptible than others.
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