Ad
related to: reed sternberg cells pathology outlines
Search results
Results From The WOW.Com Content Network
Reed–Sternberg cells (also known as lacunar histiocytes for certain types) are distinctive, giant cells found with light microscopy in biopsies from individuals with Hodgkin lymphoma. They are usually derived from B lymphocytes , classically considered crippled germinal center B cells.
Lymphocyte predominant (LP) ("popcorn") cells are present embedded in nodules consisting of B cells [10] and other reactive cells (mainly reactive T cells). [9] Reed-Sternberg and Hodgkin (RSH) cells are rarely seen, and immunohistochemistry shows a different pattern on the malignant cells; RSH cells typically express CD15 and CD30, whereas LP ...
The Reed–Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45−, CD30+, CD15+/− immunophenotype. In approximately 50% of cases, the Reed–Sternberg cells are infected by the Epstein–Barr virus. [39]
It is composed of large tumor nodules with lacunar Reed–Sternberg cell (RS cells) surrounded by fibrotic collagen bands. [ citation needed ] The British National Lymphoma Investigation further categorized NSHL based upon Reed–Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first ...
Dorothy Mabel Reed Mendenhall (September 22, 1874 – July 31, 1964) was a prominent pediatric physician specializing in cellular pathology. In 1901, she discovered that Hodgkin's disease was not a form of tuberculosis , by noticing the presence of a special cell, the Reed–Sternberg cell which bears her name. [ 1 ]
943 21941 Ensembl ENSG00000120949 ENSMUSG00000028602 UniProt P28908 Q60846 RefSeq (mRNA) NM_001243 NM_001281430 NM_152942 NM_009401 RefSeq (protein) NP_001234 NP_001268359 NP_033427 Location (UCSC) Chr 1: 12.06 – 12.14 Mb Chr 4: 144.99 – 145.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane ...
The involved lymphoid tissues in EBV+ B cell cases contain proliferating Immunoblasts (i.e. activated B cells), plasma cells, and Reed-Sternberg-lide cells. [1] The EBV+ cells in CAEB express primarily LMP1, LMP2, and EBNA1 viral proteins and EBER microRNAs, [16] suggesting that the virus is in its latency II phase. [1]
A Reed–Sternberg cell and normal lympohcytes. The histopathology of the involved tissues in HL-RT is diagnosed based of the presence of Reed-Sternberg cells (here termed RS cells). The adjacent micrograph shows a typical RS cell, surrounded by normal lymphocytes.