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Lercanidipine (trade name Zanidip, among others) is an antihypertensive (blood pressure lowering) drug. It belongs to the dihydropyridine class of calcium channel blockers , which work by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body.
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In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [ 1 ] [ 2 ] The term "effective dose" is used when measurements are taken in vivo , while "effective concentration" is used when the measurements are taken in vitro .
Dosage typically includes information on the number of doses, intervals between administrations, and the overall treatment period. [3] For example, a dosage might be described as "200 mg twice daily for two weeks," where 200 mg represents the individual dose, twice daily indicates the frequency, and two weeks specifies the duration of treatment.
A downward dose adjustment may be necessary with this particular instance of polypharmacy. [2] Severe hypotension was reported with fentanyl anesthesia when it was combined with other calcium channel blockers. Even though isradipine, another calcium channel blocker, has not been used in conjunction with fentanyl anesthesia in any studies ...
Barnidipine is a pure S,S isomer, a lipophilic 1,4-dihydropyridine calcium channel blocker, which, like other compounds in the class, shows a high affinity for calcium channels, particularly the L-type slow channels of smooth muscle cells found in the vessel wall. [2]
The maximum dose of Ozempic is 2.0 mg, to be taken once weekly. It is an injectable medication approved for diabetes management, though people on it may lose weight. ... "The typical dosage of ...
For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.