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If a person is known to usually stop convulsing after only one or two diazepam doses, it may be preferable because sedative after effects will be less than if a single dose of lorazepam is given (diazepam anticonvulsant/sedative effects wear off after 15–30 minutes, but lorazepam effects last 12–24 hours). [100]
IC 50 / pIC 50 values represent binding affinity only and do not reflect efficacy or pharmacokinetics, and some compounds listed are GABA A antagonists rather than agonists (e.g. flumazenil). Low IC 50 or high pIC 50 values indicate tighter binding (pIC 50 of 8.0 = IC 50 of 10nM, pIC 50 of 9.0 = IC 50 of 1nM, etc.)
Kindling due to substance withdrawal is the neurological condition which results from repeated withdrawal episodes from sedative–hypnotic drugs such as alcohol and benzodiazepines.
There is no known cure for protracted benzodiazepine withdrawal syndrome except time, [20] however, the medication flumazenil was found to be more effective than placebo in reducing feelings of hostility and aggression in patients who had been free of benzodiazepines for 4–266 weeks. [92]
“I’ve got Ativan here. It’s less addictive.” It had taken me months to get off Ativan, which I had done the year before, using Valium to taper down. For me it has gone: 1985 - 2009 Booze, and occasionally a little cocaine, speed or weed. 2009 - 2010 Baclofen, Ativan, lithium, Wellbutrin, Zoloft, and two or three others with chemical names
Therapeutic dose dependence is the largest category of people dependent on benzodiazepines. These individuals typically do not escalate their doses to high levels and generally use their medication as intended by their prescriber. Smaller groups include patients escalating their dosage to higher levels and drug misusers as well.
“We do not consider a plant like kratom to be any more controversial than other plants found in our food supply,” they say. “Plants are complex and require you to take the time to thoroughly ...
"If you are 18 hours late, skip it and take the normal scheduled dose at the next scheduled time." It's generally best not to try to compensate by taking more medication than normal the following day.