Search results
Results From The WOW.Com Content Network
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...
5-HTTLPR (serotonin-transporter-linked promoter region) is a degenerate repeat (redundancy in the genetic code) polymorphic region in SLC6A4, the gene that codes for the serotonin transporter. Since the polymorphism was identified in the middle of the 1990s, [1] [2] it has been extensively investigated, e.g., in connection with neuropsychiatric ...
The most studied candidate genes and polymorphism related to personality, with the most informative meta-analyses, are DRD4 and 5HTT. DRD4 encodes for the D4 dopamine receptor, while 5HTT encodes for a serotonin transporter responsible for the reuptake of this neurotransmitter. [1]
The 5-HTTLPR gene codes for the number of serotonin transporters in the brain, with more serotonin transporters causing decreased duration and magnitude of serotonergic signaling. [104] The 5-HTTLPR polymorphism (l/l) causing more serotonin transporters to be formed is also found to be more resilient against depression and anxiety. [105] [106]
Its function has been known to be influenced by serotonergic dysfunction (low levels of serotonin) which is primarily associated with the 5HTTLPR gene. [33] This gene polymorphism promotes hyperactivity of the amygdala through decreased pre-frontal cortex activity following the exposure to negative stimuli. [34]
rs6295, also called C(-1019)G, is a gene variation—a single nucleotide polymorphism (SNP)—in the HTR1A gene.It is one of the most investigated SNPs of its gene. [1] The C-allele is the most prevalent with 0.675 against the G-allele with 0.325 among Caucasian.
In genetics, rs6311 is a gene variation—a single nucleotide polymorphism (SNP)—in the human HTR2A gene that codes for the 5-HT 2A receptor. 5-HT 2A is a neuroreceptor, and several scientific studies have investigated the effect of the genetic variation on personality, e.g., personality traits measured with the Temperament and Character ...
Polymorphisms in the tryptophan hydroxylase gene was found to be tentatively associated with suicidal behavior. [20] A meta analysis of 182 case controlled genetic studies published in 2008 found Apolipoprotein E epsilon 2 to be protective, and GNB3 825T, MTHFR 677T, SLC6A4 44bp insertion or deletions, and SLC6A3 40 bpVNTR 9/10 genotype to ...