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The protein encoded by this gene is a non-selective calcium-permeable cation channel and is part of the Transient Receptor Potential ion channel super family. The closest relative is the cold and menthol activated TRPM8 ion channel. While TRPM2 is not cold sensitive it is activated by heat. [5]
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPVL ("VL" for vanilloid-like), TRPM ("M" for melastatin), TRPS ("S" for soromelastatin), TRPN ("N" for mechanoreceptor ...
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The transient receptor potential Ca 2+ channel (TRP-CC) family is a member of the voltage-gated ion channel (VIC) superfamily and consists of cation channels conserved from worms to humans. [1] The TRP-CC family also consists of seven subfamilies (TRPC, TRPV, TRPM, TRPN, TRPA, TRPP, and TRPML) based on their amino acid sequence homology:
TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi. [2]
The three proteins TRPML1, TRPML2 and TRPML3 are encoded by the mucolipin-1 , mucolipin-2 and mucolipin-3 genes, respectively. The three members of the TRPML ("ML" for mucolipin) sub-family are not extremely well characterized. [1] TRPML1 is known to be localized in late endosomes. [2]
The product of this gene belongs to the family of transient receptor potential (TRP) channels. [6] TRP channels are Ca 2+ permeable non-selective cation channels that play roles in a wide variety of physiological processes, including calcium signaling, heat and cold sensation, calcium and magnesium homeostasis.
IP address management (IPAM) is a methodology implemented in computer software for planning and managing the assignment and use of IP addresses and closely related resources of a computer network. It does not typically provide Domain Name System (DNS) and Dynamic Host Configuration Protocol (DHCP) services, but manages information for these ...