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Hepatitis B infection has been preventable by vaccination since 1982. [4] [12] As of 2022, the hepatitis B vaccine is between 98% and 100% effective in preventing infection. [1] The vaccine is administered in several doses; after an initial dose, two or three more vaccine doses are required at a later time for full effect. [1]
HBsAg (hepatitis B surface antigen) was the first hepatitis B virus protein to be discovered. [15] It consists of small (S), medium (M) and large (L) protein. [16] HBcAg (hepatitis B core antigen) is the main structural protein of HBV icosahedral nucleocapsid and it has function in replication of the virus. [17]
Viral hepatitis is liver inflammation due to a viral infection. [1] [2] It may present in acute form as a recent infection with relatively rapid onset, or in chronic form, typically progressing from a long-lasting asymptomatic condition up to a decompensated hepatic disease and hepatocellular carcinoma (HCC).
When placed at random, the transposon may be placed next to a virulence factor or placed in the middle of a virulence factor gene, which stops the expression of the virulence factor. By doing so, scientists can make a library of the genes using these markers and easily find the genes that cause the virulence factor.
Hepatitis D is a defective virus that requires hepatitis B to replicate and is only found with hepatitis B co-infection. [17] In adults, hepatitis B infection is most commonly self-limiting, with less than 5% progressing to chronic state, and 20 to 30% of those chronically infected developing cirrhosis or liver cancer. [ 31 ]
Hepatitis virus-associated hepatocarcinogenesis is a serious health concern. [31] Liver cancer in the United States is primarily due to three main factors: hepatitis C virus (HCV) (22%), hepatitis B virus (HBV) (12%) and alcohol use (47%). [32] In 2017 there will be about 40,710 new cases of liver cancer in the United States. [33]
Virus factors are largely influenced by viral genetics, which is the virulence determinant of structural or non-structural proteins and non-coding sequences. For a virus to successfully infect and cause disease in the host, it has to encode specific virus factors in its genome to overcome the preventive effects of physical barriers, and ...
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...