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Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. [7] It is generally recommended only for people who cannot take allopurinol. [8] [9] It is taken by mouth. [7] Common side effects include liver problems, nausea, joint pain, and a rash. [7]
Choice of additive solution has an impact on the red blood cell viability and, thereby, shelf life (expiry date) of the red blood cell concentrate. Usually, shelf life is limited to 4 to 6 weeks, provided that the red blood cell concentrates are stored in adequate conditions (2-6 °C). Commercial additive solutions are typically based on saline.
A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]
[8] [6] While use during pregnancy does not appear to result in harm, this use has not been well studied. [1] Allopurinol is in the xanthine oxidase inhibitor family of medications. [7] Allopurinol was approved for medical use in the United States in 1966. [7] It is on the World Health Organization's List of Essential Medicines. [10]
The PDUFA date thus serves as a 'best estimate' of when a decision on a New Drug Application or a Biologics License Application would be forthcoming. This response may be a decision to approve the application or a Complete Response Letter (CRL). The PDUFA date may be extended by the Food and Drug Administration in certain circumstances. [6]
Memory B cell activity in secondary lymphatic organs is highest during the first 2 weeks after infection. Subsequently, after 2 to 4 weeks its response declines. After the germinal center reaction the memory plasma cells are located in the bone marrow which is the main site of antibody production within the immunological memory. [12]
Under the cooperative development, this tunnel was enlarged to 30 feet (9.1 m) in diameter. The 7.2-mile (11.6 km) long tunnel, including the penstocks, drops water 1,060 feet (320 m) between Pyramid Lake and the hydroelectric power facilities, and carries over five times the flow previously contemplated for the 17-foot (5.2 m) tunnel.
This article may be too long to read and navigate comfortably. Consider splitting content into sub-articles, condensing it, or adding subheadings. Please discuss this issue on the article's talk page. (October 2024) January 6 United States Capitol attack Part of attempts to overturn the 2020 United States presidential election and domestic terrorism in the United States Crowd outside the ...