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N-acetylcysteine, also known as Acetylcysteine and NAC, is a medication that is used to treat paracetamol (acetaminophen) overdose and to loosen thick mucus in individuals with chronic bronchopulmonary disorders, such as pneumonia and bronchitis. [9]
Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol. Studies have reached conflicting conclusions regarding the clinical significance of this incremental pain relief. [20] [21]
Calcium lactate gluconate, also known as GLOCAL, is a soluble salt of calcium, lactic acid and gluconic acid used in effervescent calcium tablets. [1] Its chemical formula is Ca 5 (C 3 H 5 O 3) 6 ·(C 6 H 11 O 7) 4 ·2H 2 O. It was first developed by Sandoz, Switzerland.
Paracetamol's bioavailability is dose-dependent: it increases from 63 % for 500 mg dose to 89 % for 1000 mg dose. [6] Its plasma terminal elimination half-life is 1.9–2.5 hours, [ 6 ] and volume of distribution is roughly 50 L. [ 132 ] Protein binding is negligible, except under the conditions of overdose, when it may reach 15–21 %. [ 6 ]
Effervescent tablets mostly come in capsules constructed for these tablets. They may contain an anti-bacterial coating and are water resistant. The cap contains a little spring-like spiral, which helps keeping the tablets in place during transportation and prevents them from breaking. The cap also contains little balls made out of silica gel. [18]
Effervescent tablets are tablets which are designed to dissolve in water, and then release carbon dioxide. [21] [22] [23] Common ingredients include citric acid and sodium bicarbonate, which react when in contact with water to produce carbon dioxide. Effervescent antacids may also contain aspirin, [24] sodium carbonate, or tartaric acid. [25]