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Muscle cramps, also known as muscle spasms or charley horses, are the involuntary contraction of muscle fibers, says Dr. Lucas Buchler, a physician of sports medicine and orthopaedic surgery at ...
Charley horses have many possible causes directly resulting from high or low pH or substrate concentrations in the blood, including hormonal imbalances, dehydration, low levels of magnesium, potassium, or calcium (evidence has been mixed), [5] [6] [7] side effects of medication, or, more seriously, diseases such as amyotrophic lateral sclerosis and neuropathy. [8]
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Muscle stiffness may also be present; if muscle weakness is not also present, and cramps are more severe, the stiffness may be categorized instead as cramp fasciculation syndrome. [3] Cramp fasciculation is a variant of BFS which presents with muscle pain and exercise intolerance. [2] [4]
Quinine has not been shown to reduce the duration (length) of a muscle cramp. [6] Quinine treatment may lead to haematologic and cardiac toxicity. Due to its low effectiveness and negative side effects, its use as a medication for treating muscle cramps is not recommended by the FDA. [26] Magnesium is commonly used to treat muscle cramps.
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